Abstract: A three dimensional supramolecular hydrogel consisting of prodrug-modified graphene oxide and alpha-cyclodextrin was developed. This hydrogel with a well-ordered interior microstructure integrated hydrophobic and hydrophilic anticancer drugs into a single multifunctional platform, and underwent a gel-sol transition leading to cascade release of two drugs in an on-demand fashion upon NIR light irradiation. 

KeyWords Plus: PHOTOTHERMAL THERAPY; ALPHA-CYCLODEXTRIN; DELIVERY; PRODRUGS; COPOLYMERS; CODELIVERY 

Published in CHEMICAL COMMUNICATIONS, 52 (100):14384-14387; 10.1039/c6cc08123a 2016