Abstract: An aerobic oxidative aromatization of simple aliphatic alcohols and anilines under the Pd(OAc)(2)/2,4,6-Collidine/Bronsted acid catalytic system has been established, providing a direct approach for the preparation of diverse substituted quinoline derivatives in high yields with wide functional group tolerance. Practically, the protocol can be easily scaled up to gram-scale and was utilized in the concise formal synthesis of a promising herbicide candidate.

KeyWords Plus: PHOTOCATALYTIC SYNTHESIS; CONTAINING CATALYSTS; N-HETEROCYCLIZATION; TIO2 NANOPARTICLES; MOLECULAR-OXYGEN; DERIVATIVES; NITROARENES; 2-METHYLQUINOLINES; DEHYDROGENATION; HYDROGENATION 

Published in JOURNAL OF ORGANIC CHEMISTRY, 82 (6):3284-3290; 10.1021/acs.joc.6b03064 MAR 17 2017